KPV Research Guide: Alpha-MSH Fragment Science
KPV (Lys-Pro-Val) is a synthetic tripeptide corresponding to the C-terminal amino acids 11-13 of alpha-melanocyte stimulating hormone (α-MSH). It has been studied in preclinical models for its anti-inflammatory properties and potential role in gut barrier function, and was among the compounds reviewed by the FDA’s Pharmacy Compounding Advisory Committee in July 2026.